Activity of cinnamaldehyde, carvacrol and thymol combined with antifungal agents against <i>Fusarium</i> spp

Fusarium spp. are able to cause a wide range of opportunistic infections in both immunocompromised and immunocompetent individuals. Thus, new therapeutic options should be considered. We evaluated the antifungal activity three phytocompounds (cinnamaldehyde, CIN; carvacrol, CRV; thymol, THY), as well their activities when combined with amphotericin B (AMB), caspofungin (CAS), itraconazole (ITC) voriconazole (VRC) against 20 clinical isolates Fusarium. Broth microdilution (M38-A2) checkerboard methodologies were used obtain MICs (Minimum inhibitory concentration) FICIs (Fractional Inhibitory Concentration Index), respectively. The observed for were: 20–80 CIN, 40-> 320 CRV 40–320 µg/mL THY. most effective combinations (synergism rates) THY + CAS (96%), (88%), AMB (76%), (68%), VRC (68%) (60%). Our findings suggest that have potent CAS, or VRC.